GETTINGITRIGHT
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With expected flat stakes POT being equal a higher strike rate lets you safely bet more using the same bank than a lower expected strike rate. With safety being the chance of not losing your bank.
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First off remove the word "safety" from your vocabulary. There is no such thing as a safe bet. Even thinking that way can distract the way you bet by taking the "safer choice" option. eg: the horse paying the least of your selections, the one with the better form.

Secondly there is no difference between having a strike rate of 5 from 10 at an average dividend of $2 compared to a strike rate of 1/10 at $10. The POT is the same.

Once you have an established strike rate from your selection method and a betting method then appling the two together gives you your POT. Its a matter of not accepting odds below a certain level that will establish your POT in the black.

example. Your s/r is 1/10 then you need $10 winners to break even at level stakes.

You could increase the stakes on lesser dividends but you then increase the RISK FACTOR. You may win but you would more than likely be playing catchup all the time.